AB0408 SYSTEMIC SCLERODERMA AND ENVIRONMENTAL RISK FACTORS: IDENTIFYING ASSOCIATIONS MINING THE BIOMEDICAL LITERATURE

Background: A debate still exists concerning the role of occupational and environmental factors in pathogenesis systemic scleroderma (SSc). Objectives: Our aim was to explore associations between SSc utilizing an automatic semantic interpretation PubMed results. Methods: The literature search string: (“systemic sclerosis” OR “scleroderma”) AND (“occupational exposure” “environmental” “risk factor”) used retrieve abstracts from entire database, using Semantic MEDLINE 2, on 6/14/2020. This application represents a network predications (triples form subject-predicate (or relation) -object, e.g. Occupational Exposure causes Systemic Scleroderma) knowledge graph. Subject object arguments each predication are concepts Unified Medical Language System (UMLS) Metathesaurus relation is taken UMLS Network. system allows for choosing central topic (“Systemic Scleroderma”), length (3 nodes), summarization, eliminating less informative predications. Results: string retrieved 864 citations identified 6,397 by 34 types relations. Initially, we focused our attention ‘CAUSES’ type (Figure 1), displaying with 59 nodes 57 edges. this network, as having causal relationship autoimmune diseases/autoimmunity, chemicals such bleomycin, exposure, especially silica, vinyl chloride trichloroethylene, genes, including HLA non-HLA genetic polymorphisms, transcription (TFs) Fli1 KLF5, fibrosis. Eosinophilia-myalgia syndrome, toxic oil syndrome infection were all causally linked diseases. Minerals associated exposure Concepts fibrosis rare diseases, other STAT4, IR4, IR5, TLR4, TLR7 Rho-associated Kinase, monomer. Pathogenic endothelial dysfunction extracellular matrix proteins. Many papers also suggested that hormonal involved. Conclusion: Inspection graphs reveals research etiopathogenesis SSc. relations which these participate, provide more specific information. graph supports kind patterns underpin literature-based discovery. Although remains elusive, it accepted initial vascular damage driven autoimmunity abnormalities vasculature resulting activation fibroblasts various organs. Silica solvents trichloroethylene seem be most consistently suspected agents References: [1]Rindflesch TC,et al. MEDLINE: An advanced information management biomedicine. Information Services & Use 2011;31:15-21. Figure 1. Network Casual Relationships Scleroderma. Disclosure Interests: None declared